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True eradication requires global coordination and has currently only been achieved for smallpox

BRPF1 contains a bromodomain, which is reported to bind H2AK5ac, H4K12ac, and H3K14ac (Poplawski et al, 2014), and two PHD fingers closely linked by a zinc knuckle, which bind to unmodified histone H3 tail and nucleosomal DNA (Klein et al, 2016)

Superoxide-generated peroxynitrite and H 2 O 2 upregulate arginase-2 [27]

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Cell Death Dis 8 , e2848 (2017)
