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This is not true pharmacological tolerance in the classic sense, but rather the body finding a new equilibrium at the current level of receptor stimulation

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Study Profile Efficacy and safety of HS-20094 in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, phase 2 trial Format: Short Oral Discussion Presentation#: 732 Corresponding author: Department of Endocrinology, Peking University First Hospital, Beijing, China, Junqing Zhang First author: Department of Endocrinology, Peking University First Hospital, Beijing, China, Lin Liu Date: September 12, 2024,14:00 (CEST) Introduction and Objective HS-20094 is a novel dual GIP and GLP-1 receptor agonist