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By analysing epigenetic silencing modifications (H3K27me3), Dror et al [46] identified two beta cell subtypes (beta-high and beta-low), matching clusters previously identified in mice and humans, including beta1/beta2 from Dorrell et al [47] and INS high/low from Chiou et al [48]

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Likewise, there is greater proliferation of human umbilical vein endothelial cells (HUVECs), significantly promoted migration of HUVECs (transwell assay), and the upregulated expression of VEGF-a, and accelerated vascular tube formation in vitro (Huang et al., 2015)

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The results, depicted as boxes and whisker plots, indicate the median value, the mean, and the distribution of values with the minimal and maximal points ("whiskers")