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Semaglutide acts as a GLP-1 receptor agonist that binds to and activates GLP-1 receptors

The expression of GLP-1 and/or GLP-1R was found in hypothalamic feeding centers (28, 29), hindbrain matrix (30), the lateral parabrachial nucleus of the posterior nucleus (31), and mesolimbic substrates (3234), etc

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GLP-1, or glucagon-like peptide-1, is a hormone naturally produced in the gut