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GLP-1 also affects these factors (except sex and medication)

There is high certainty that the net benefit is moderate or there is moderate certainty that the net benefit is moderate to substantial

J Clin Invest 79, 616619 (1987)

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They are rapidly and efficiently absorbed after oral administration, exhibiting high bioavailability ranging from 67% to 100%, except for linagliptin, which has a bioavailability of 30% as a result of its first pass metabolism in the intestine and hepatocyte, and limited membrane permeability [73, 74] (Table 1)