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Zhang et al., 2022) have found that incretin receptor agonists (Exendin-4 and DA-JC4) and GLP-1/GIP dual receptor agonists DA5-CH can successfully cross the blood-brain barrier and reach the pathological area of PD, which is expected to become an ideal therapeutic drug

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cAMP dose-dependently prevents palmitate-induced apoptosis by both protein kinase A-and cAMP-guanine nucleotide exchange factor-dependent pathways in -cells