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Additionally, GLP-1 agonists improve metabolic functions by increasing the production of short-chain fatty acids like butyrate, propionate, and acetate, which serve as energy sources for colonocytes, modulate immune responses, and enhance the production of gut hormones that regulate appetite and glucose homeostasis

No significant differences were observed for myocardial infarction, stroke, or revascularization with risk differences of 0.1% (95% CI 1.0 to 0.8%), 0.8% (95% CI 0.2 to 1.7%), and 0.2% (95% CI -0.71.1%), respectively

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Metformin and SGLT-2 inhibitors can be safely combined with tirzepatide for glucose control and weight management, while phentermine combination is not recom...

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