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This analytical framework facilitates the calculation of effect size estimates within each stratified subgroup, thereby enhancing the precision of adverse drug reaction (ADR) signal detection

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81,82 The endogenous GLP-1 is difficult agent for therapeutic use because of the rapid cleavage of the dipeptide His 7 -Ala 8 by DPP-IV, which leads to a loss of receptor interaction and insulinotropic action