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doi: 10.1016/S1044-0305(96)00233-4

The oncoprotein HBXIP up-regulates Skp2 via activating transcription factor E2F1 to promote proliferation of breast cancer cells

By conferring resistance to a number of chemotherapeutic drugs, an important 2004 study published in the Cell Biochemistry and Function highlights, Elevated levels of glutathione in tumor cells are able to protect such cells in bone marrow, breast, colon, larynx and lung cancers. The reverse is also true

Based on these observations, it is possible to infer a role of cortisol in the gender difference of GSH level, as in elderly women, urinary free cortisol excretion is lower than in the elderly men [63]

Kavoussi RJ, Hauger RL, Coccaro EF (1999)

1998 Jan 1;18(1):156163