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The use of diclofenac, particularly at doses = 100 mg / day and during prolonged treatments, may be associated with an increased risk of arterial thrombotic events, such as myocardial infarction or stroke

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Important factors potentiating AKI in these patients are extracellular volume depletion due to vomiting, diarrhoea, urinary tract obstruction, fluid and electrolyte disturbances, exposure to contrast media, nephrotoxic antibiotics, non-steroidal anti-inflammatory drugs and nephrotoxicity of some of the anti-cancer treatments [24]
