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(2019) found that the caspase-8 mutation promotes hair cell survival and resistance to cisplatin toxicity by the inhibition of apoptosis, demonstrating the key role of caspase-8-mediated apoptosis in the ototoxicity of cisplatin both in vitro and in vivo experimental contexts

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When NNMT is overactive (common in obesity), cells struggle with energy production and metabolic efficiency

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