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Zachariah et al (22) described multiple doses of chemotherapy used for a 55-year-old man with NICTH due to a large retroperitoneal undifferentiated mesenchymal tumor, but noted that the patient deteriorated and died over the next few months

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A 2023 review of 14 studies found that combining esketamine with standard antidepressants can be an effective treatment for people with treatment-resistant depression

In general, B vitamins enter the body as prodrugs and must be metabolized to their active "coenzyme" forms
