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Less food noise: GLP1 can reduce food noise by signaling satiety to your brain

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Metformin, an activator of AMPK and LKB1, could decrease hepatic tissue insulin resistance, and prolonged survival was observed in cancerous metformin users (Sadeghi et al., 2012

This fatigue reflects your body adapting to reduced caloric intake and metabolic changes

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5 This means it doesnt compete with drugs that are processed by the liver