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pH 7.39, osmolarity 320 mOsm) with 10 nM ghrelin or 10 nM GLP-1

Monitor key labs

Human data on GLP-1 use in pregnancy is limited, but available studies suggest no higher fetal risk than insulin, while animal studies show potential developmental concerns

A central dispute involves testing duration

Shared Decision-Making : Treatment decisions should involve the adolescent, their family, and a multidisciplinary healthcare team

Introduction The biological effects of the Glucagon-like peptide-1 (GLP-1) are mediated by binding to its receptor, GLP-1R, a specific seven-transmembrane receptor guanine nucleotide-binding protein (G-protein) coupled receptor (GPCR) (1)