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Description
Steatosis inhibits liver cell store-operated Ca 2+ entry and reduces ER Ca 2+ through a protein kinase C-dependent mechanism

GLP-1RA can also play a cardioprotective role by increasing autophagy, inhibiting cardiomyocyte apoptosis, reducing the expression of inflammation-related proteins (30), reducing cardiomyocyte apoptosis induced by hyperglycemia (31), and improving myocardial energy metabolism

Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: studies with the antagonist exendin 9-39
Results were published in the New England Journal of Medicine in 2025

However, given the novelty of this therapeutic approach, the available evidence may be influenced by publication bias and early optimism, and long-term mechanistic and clinical outcome data remain limited
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