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These differentially expressed proteins can serve as candidate biomarkers for diagnosis, prognosis, or treatment stratification, and inform subsequent targeted validation

Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis
Genomics 2012 pii: S0888-7543(12)00228-5
Molecular oxygen (O 2 ) can unpair and leave free radicals which are highly unstable and reactive, leading to the formation of ROS [45, 46]

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