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Few studies in animals have indicated that GLP-1 RAs may affect the tone of coronary arteries through inhibition of vasospasm or promotion of vasodilatation (Xiong et al., 2019

33 These observational findings align with realworld adherence to other glucoselowering medications

M., Martinou, E

The attenuation of effect with tachyphylaxis primarily reduces the delay in gastric emptying, with long-acting formulations showing less consistent slowing of emptying compared to short-acting agents

In the wake of their growing marketability as a weight-loss tool, researchers are examining other ways GLP-1 drugs may influence our behavior and whether they could treat a broader range of health challenges

Effects of semaglutide and empagliflozin on oxygenation, vascular autoregulation, and central thickness of the retina in people with type 2 diabetes: a prespecified secondary analysis of a randomised clinical trial