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This effect has been previously demonstrated in an infant rat model of pneumococcal meningitis 17 and in whole blood cultures from human patients with acute COVID-19 18

Moreover, this may be a fully controlled response providing, for instance, in the counteraction of tumor-induced cachexia, the inhibition of catabolic pathways (IL-6, TNF-alpha) balanced with the stimulation of anabolic pathways (FoxO3a, p-AKT, p-mTOR, and P-GSK-3) [6]