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Another study showed that calmangafodipir protected against small fiber neuropathy in an oxaliplatin-induced BALB/c mouse model, and interestingly, in addition to consistent with previous findings, calmangafodipir showed a U-shaped effect, with the 10 mg/kg dose less effective than the 2.5 and 10 mg/kg doses [156]

Intestinal epithelial cells also express most TLRs and both NODs, among which TLR2 and TLR4 signaling may influence the integrity of TJ complexes

Gut-microbiota-based interventions represent a promising strategy for the treatment of neuropsychiatric disorders, including ASD

Since the term was first coined, by Sterling and Eyer (1988), the concept of allostasis has primarily been used in the literature to describe mild perturbations that are stress related, psychosomatic and/or psychopathological (Tannenbaum et al., 2002