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Many researchers report this combination outperforms either method alone

This is one of the more interesting questions in the Dihexa story

*Digestive Diseases and Sciences*, 42(12), 2420-2428

In the pivotal 2017 Cell paper quoted earlier, one of the unexpected benefits was increased fur density in mice treated with FOXO4-DRI: Underscoring their aging phenotype, XpdTTD/TTD mice show accelerated loss of hair

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Through co-immunoprecipitation (CO-IP) experiments, we discovered that FOXO4-DRI prevents the binding of FOXO4 to P53, facilitating the phosphorylated P53 nuclear exclusion, which subsequently trigger BAX and cleaved caspase-3, leading to the apoptosis of senescent cells