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The usual dose for vitamin B12 injections is 1000 mcg (1 mg), given by injection

discard if cloudiness or particles are present

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Titration: There is generally no need for upward titration with B-complex vitamins as one might do with certain drugs, but if a patient is frail or known to react to injections, the provider may choose to start at a lower dose (for example 0.25-0.5 mL) and then increase to 1 mL as tolerated

In particular, cellular metabolic state is in constant communication with mitochondrial homeostasis

Typically, the positive effects last from about a week up to a month, though this can vary based on how your body absorbs and utilizes the vitamin, as well as your overall health