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In controlled studies performed in rats, the combination of acetaldehyde and nicotine created a much stronger addiction than with nicotine alone

Youth are not just experimenting with e-cigarettes but are reporting frequent usean indicator of addiction

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One study investigated the acute effect of a nicotine patch on cannabis induced psychotomimetic effects (using the Addiction Research Center Inventory: LSD subscale) where nicotine had no effect on THC (Penetar et al