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The Ultra-Long Acting LAPSGLP/GCGdual Agonist, HM12525A, Demonstrated Safety and Prolonged Pharmacokinetics in Healthy Volunteers: A Phase 1 First-in-Human Study

CCK stimulation of GLP1 neurons involves alpha1adrenoceptormediated increase in glutamatergic synaptic inputs

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However, direct biomarker evidence in NDD populations is limited, and the relative contributions of central versus systemic immune modulation remain uncertain