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To overcome these limitations, this review discusses a range of structural modifications, including N-terminal and C-terminal substitutions, fatty acid conjugation, and large molecule fusion technologies, which have collectively contributed to enhanced half-life, increased stability, improved receptor affinity, and retained or augmented bioactivity of GLP-1 analogs

Lancet Diabetes endocrinol (2021) 9(10):65362

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The company has now added compounded GLP-1 injections with the same active ingredient as buzzy branded weight loss drugs Ozempic and Wegovy, executives said

However, their use raises important clinical considerations