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BMC Health Services Research 12(1):1

Manufactured by Novo Nordisk, Ozempic contains the active ingredient semaglutide, which mimics a hormone that regulates insulin production and appetite

However, GLP-1 RA is only indicated for obesity treatment in individuals who have not achieved their weight loss goals despite positive lifestyle changes and whose body mass index (BMI) remains above 25 kg/m2

Sarwer DB, Hanson AJ, Voeller J, Steffen K

Soty, M., Gautier-Stein, A., Rajas, F

Moreover, LPS treatment upregulated nuclear NF-b p65 (pS536) protein levels, while exendin-4 reduced nuclear NF-B p65 (pS536) levels, suggesting that GLP-1 analogs may modulate inflammatory cytokine expression by interfering with NF-B p65 phosphorylation and translocation to the nucleus (Figure 7)