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Acknowledgements We thank FigDraw for providing the online illustration platform, and Figures 1 and 2 were generated by FigDraw

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Patients in the control treatment group received standard care, while those in the hydrogen therapy group consumed HRW orally (12001800 mL/day, twice daily) for 6 weeks in addition to standard care

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The paradoxical finding of reduced oxidative stress alongside increased NF-B and Bax in the PRP/PC group can be explained by the time-dependent and biphasic nature of PRP signaling

We observed knockdown of NRF2 protein and robust growth inhibition upon dox treatment, highlighting the dependency of these cell lines on NRF2 for growth (Fig