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C.AlsharifI.MazzaR.LefrancB.et al (2018)

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For drug that is absorbed into the conjunctiva following topical application, only approximately 0.1% of the dose may reach the retina through transscleral diffusion after much of the drug is lost via systemic absorption through the conjunctival blood vessels [17,18,19]

Moreover, a lower level of glycine was observed in liver and colon tissues, which indicates that the gut microbiota regulates glutathione metabolism, not only in the small intestine but also in the liver and the colon