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When food enters the digestive system, GLP-1 is released and acts on multiple targets: it stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and promotes satiety through central nervous system pathways

Wegovy has a starting dose of 0.25mg once per week, to be taken over a 4-week period

It may also reduce androgen signaling

Lack of baseline measurements for liver steatosis and fibrosis before the initiation of the EDICT study, as well as the small number of patients enrolled were the main limitations of this trial