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Cai CX, Nishimura A, Baxter S, et al

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Pharmacologic studies in animals have shown that suppression of food intake after peripheral administration of the GLP-1 receptor agonists exendin-4 and liraglutide is mediated by activation of GLP-1R expressed on vagal afferents as well as direct CNS GLP-1R activation, highlighting the importance of the interaction between peripheral and central receptors [31]

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