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Our interest in this combination arose because both drugs individually have been shown to have anti-tumor effects in pancreatic cancer, read a statement from two of the authors of the paper: Chi Dang, director of the Ludwig Institute for Cancer Research and Anirban Maitra, scientific director of the Center for Pancreatic Cancer Research at MD Anderson Cancer Center

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Numerous studies have investigated the expression patterns of endogenous GLP-1 and GLP-1R in the central nervous system (CNS) and the peripheral nervous system, with a consensus that these are expressed on neurons and found in most areas of the brain and gutbrain axis 2

Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes

I would like to point out that it took him 13 months to come to that decision