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Firstly the Review was based on research papers that were very suspect and involved groups of individuals that did not represent a wide cross section of society (the primary study was of mainly elderly males)

This makes B12 supplementation extremely safe, with a low risk of toxicity
Folate alone can improve blood findings while B12-related nerve injury continues, so diagnosis and follow-up are important before changing products or adding supplements
The vitamin B12 injection is usually injected subcutaneously (just under the skin) into fatty tissue

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