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Lipscombe L, Butalia S, Dasgupta K, et al

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Use caution in a patient with a history of angioedema or anaphylaxis with another GLP-1 receptor agonist Acute Gallbladder Disease: Acute events of gallbladder disease such as cholelithiasis or cholecystitis have been reported in GLP-1 receptor agonist trials and postmarketing

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Additionally, treatment with GLP-1RA and exendin-4 increased the expression of the calcitonin gene in the thyroids of normal (wild-type) mice
