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As an example, EpiAirway tissues have been shown to be quite predictive of in vivo respiratory response to chemicals, although the comparisons were made only with a classification based on in vivo rat studies and not humans [38]
doi:10.1097/ADM.0000000000000049

A change to the schedules published in terms of the Medicines and Related Substances Act last year classified nicotine when used as a substitute for a tobacco product as a schedule three substance

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