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Weight loss: By increasing satiety and reducing food intake, as well as slowing gastric emptying, GLP-1s help reduce body weight (which further helps metabolic health)

In spite of increasing overall prevalence of conditions that contributed to the pathophysiology of HFpEF, there was considerable international variation in the prevalence of HFpEF and its contributing factors

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Dose titration strategy is critical

Participants continuing treatment with Zepbound MTD preserved all of their prior weight loss over the 1-year period, while those on the dose reduction maintained all but 5.6 kg on average

On the other hand, the cardiovascular destiny of the diabetic patient is not unavoidable, as patients with type 2 diabetes (T2D) who had major risk factors for cardiovascular disease (CVD) within the target range had little or no excess risk of CVD and mortality [4]