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This can be helpful for: Individuals with a history of GI sensitivity Those who experienced significant side effects with other GLP-1 medications People who prefer the most cautious approach possible Note: The 1mg starting dose is a community preference, not a clinical trial protocol

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After adjusting for residual confounding, the difference in weight loss between those receiving tirzepatide vs semaglutide was 2.0% (95% CI, 2.1% to 1.8%) at 3 months, 3.2% (95% CI, 3.5% to 3.0%) at 6 months, and 5.1% (95% CI, 5.8% to 4.3%) at 12 months

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