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A widely prescribed class of weight-loss and diabetes medications may be doing more than improving metabolic health.

Patient-derived human islets from male and female cadaveric donors were 3D-cultured in solubilised extracellular matrix gel in co-culture with the same donor PBMCs, and incubated with cytokines (IL-1, TNF-, IFN-) for 2448 h in the presence of vehicle or increasing concentrations of the CB1R blocker JD-5037

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In those years, Wegovy and Mounjaro, respectively, were the highest-volume and highest-utilization drivers of this overall trend.

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