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www.mayoclinic.org Synthesis Semaglutide is synthesized from two intermediate compounds by chemical reaction, with the specific steps as follows: (1) Preparation of Compound 2: Starting from Arg34GLP-1(9-37), side-chain modifications are performed on Arg34GLP-1(9-37) and the 26-Lys residue of Compound 1

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1 By preventing apoptosis, fostering synaptic regeneration, and supporting neuronal recovery, GLP-1 RAs may contribute to clinical improvement across a range of neurological disorders

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