Biomedical Reports
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Oxidized phosphatidylserine also exhibits anti-inflammatory properties [22]: it reduces neutrophil oxidative bursts by inhibiting myeloperoxidase activity [29], counteracts lipopolysaccharide-induced responses through Toll-like receptor 4 signaling in immune cells [30], suppresses interleukin-1 and TNF- production in monocytes [31], and promotes vascularization [32]
Following release, these peptides bind to opioid receptors, resulting in a variety of downstream signaling cascades based on receptor and peptide type and cellular expression
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M., Dunn-Meynell, A
2-Oxoglutarate-dependent oxygenases
Interestingly, expression of BHMT, which catalyzes the methyl transfer from betaine to homocysteine to produce dimethylglycine and methionine, was shown to be upregulated in the liver of high-fat fed mice [34,35]
