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The neuroprotective activities of GLP-1RAs against PD can be, at least partially, mediated by PI3K/AKT pathway that modulates several downstream molecules, such as cAMP response element-binding protein (CREB), glycogen synthase 3 (GSK-3), Forkhead box O1/O3 (FoxO1/O3), and mammalian target of rapamycin (mTOR) (Athauda and Foltynie, 2016) (Figure 1B)

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In another recent systematic review [29], the effects of semaglutide on body weight were evaluated in comparison to other GLP-1 RAs, including liraglutide, exenatide, dulaglutide, and, more recently, the dual GLP-1/GIP receptor agonist tirzepatide

Notable for: Multi-database design (improves generalizability) Active comparator framework Emphasis on short-term safety with acknowledgment of need for longer follow-up Diabetes Care Retrospective Cohort Evaluated thyroid tumors (broader outcome than confirmed malignancies) and found no increased risk with GLP-1 RA exposure in type 2 diabetes patients initiating second-line treatments

Much touted research increasingly supports the view that psilocybin can help patients with a range of psychiatric conditions, Kelmendi said

In T2D, loss of the suppressive effects of glucagon and insulin is associated with hyperglucagonaemia and this is thought to contribute to hyperglycaemia (4750)