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An iterative process was used, where thin plate regression splines and/or interactions between variables were added until balance was achieved
doi: 10.1111/j.1463-1326.2009.01173.x

[DOI] [PMC free article] [PubMed] [Google Scholar] 403.Couvineau A., Rouyer-Fessard C., Laburthe M

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Mauvais-Jarvis et al., 2013
Will the Precision Peptide Genetic Test reveal how I'll react to drug interactions
