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MG is detoxified by the glyoxalase route by the sequential actions of GLYI and GLYII in a glutathione (GSH)-dependent manner, while GLYIII facilitates glutathione-independent detoxification under prolonged stress conditions

Each pack contains 2 tubes with 15 tablets each, offering a convenient 30-tablet supply

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Further studies are required to understand the molecular targets involved in methotrexate- induced hepatotoxicity, as well as to translate into therapeutic approaches
