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John Eng, working at the Veterans Administration Center in the Bronx, identified a peptide in Gila monster venom he called exendin-4

This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors

In preclinical models, comparison of cotadutide, a glucagon/GLP-1 dual RA, and liraglutide demonstrated superior reduction of hepatic de novo lipogenesis and enhancement of hepatocyte mitochondrial oxidative capacity (similar to levels stimulated by glucagon mono-agonismsuggesting restoration of mitochondrial function is a glucagon-specific benefit) [39]

Supportive measures include electronic health record screening for food and nutrition security, curricular and accreditation interest in medical nutrition education, and expanded care pathways and reimbursement models [222]

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doi: 10.3390/antiox10122028