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We have assessed various metabolic parameters after short and long exposure of clonal BRIN-BD11 -cells and rodent islets to the GLP-1R agonist Exendin-4 (50 nM)

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Then a similar study was done with psoriatic arthritis with the same drug combinations: ixekizumab plus tirzepatide versus ixekizumab alone

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an effect that is maintained in mice fed a high-fat diet (17)

Am J Gastroenterol 2016;111(3):42332