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Additionally, when GLP1R knockout mice were used to validate the impact of exenatide and liraglutide, no increase in calcitonin secretion or C-cell hyperplasia was observed

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What Research Shows So Far Retatrutide has been evaluated in phase 2 obesity and metabolic disease trials, with phase 3 results beginning to appear

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It may be reasonable to focus on whether the combination of GLP-1RAs and SGLT2is, which are expected to have complementary effects based on large-scale clinical trial results, can further reduce cardiovascular and renal events in patients with diabetes

Zhu E, Yang Y, Zhang J, Li Y, Li C, Chen L, et al