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PlexusDx's $99 genetic test maps 49 peptides across 14 pathways, including GLP1R, GIPR, FTO, and MC4R variants

The atomic coordinates and electron microscopy maps have been deposited in the Protein Data Bank (PDB) under accession codes: 7DUR (compound 2GLP1RG s complex), 7DUQ (compound 2GLP-1-GLP-1RG s complex) and 7E14 (compound 2LY3502970GLP-1RG s complex) and Electron Microscopy Data Bank (EMDB) accession codes: EMD-30867 (compound 2GLP1R-G s complex), EMD-30886 (compound 2GLP-1GLP-1RG s complex) and EMD-30936 (compound 2-LY3502970GLP-1RG s complex), respectively

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Moreover, because GLP-1R is expressed throughout the body, stimulation with a GLP-1R agonist or indirectly with a DPP-IV inhibitor can have a broad systemic effect on systemic metabolism, which, in turn, ameliorates peripheral and central insulin resistance in AD and MD (Athauda and Foltynie, 2016)