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Exercise and cold exposure induce PGC-1 coactivators, amplifying ERR-dependent gene sets involved in fatty-acid uptake and -oxidation (for example, CPT1, MCAD), OXPHOS subunits, TCA cycle enzymes, and mitochondrial transcription factors (for example, TFAM)

Beneficial haemodynamic effects were also observed in HFrEF patients treated with ketone bodies [68]

Jensterle M, DeVries JH, Battelino T, Battelino S, Yildiz B, Janez A

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doi: 10.1111/dme.14287

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