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doi: 10.1080/07391102.2025.2532848

Epidermal insulin resistance as a therapeutic target in acanthosis nigricans

Diabetes Therapy , 11(4), 835846

Ther Adv Drug Saf

Omega-3 fatty acids (1 to 2g EPA/DHA daily)

The subsequent increase in cAMP leads to the activation of cAMP-regulated guanine nucleotide exchange factor 2 (cAMP-GEFII or Epac2) and protein kinase A (PKA)
