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According to immunohistochemistry analysis of colorectal cancer tissues, CD44 protein abundance was directly substantially associated with tumor grading, peritumoral budding, lymph node metastasis as well as advanced cancer stage [35]

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73,74 Tumor suppressor BRCA1-associated protein 1 (BAP1) frequently mutated or deleted in sporadic human cancers, inactivation of BAP1 inhibited ferroptosis by releasing SLC7A11 inhibition, thus BAP1 mutated cancer cells were sensitive to SLC7A11 inhibitor erastin

Ichimura, K., Mizoguchi, T., Yoshida, R., Yuasa, T

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