tirzepatide and blindness Apitegromab for lean mass preservation during tirzepatide-induced weight loss: a randomized, double-blind, placebo-controlled phase 2 trial Insights into the Mechanism of
Description
This study, together with a companion manuscript, shows that in mice, weight loss as a result of GIP receptor antagonism requires and potentiates functional GLP-1 receptor signalling in the brain, explaining how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms.

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This study compared real-world weight reduction and cardiometabolic parameters associated with tirzepatide and semaglutide for obesity management