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Three complementary assessment methods were used: Chromameter CR300 (CIE L*a*b*): Objective, instrument-based skin colour measurement

10.1097/BPO.0b013e3181652185 7 AnghelescuD

found the incidence rate of periodontitis in the subjects with gout was significantly higher than that in the comparison cohort, while the risk of periodontitis in gout patients using colchicine was significantly lower (90)

Single-point energies were calculated on the optimized geometries using the B97X-D hybrid functional 87 and the 6-311 + G(2d,p) basis set with ultrafine integration grids for the QM part and the ff14SB, gaff2 and TIP3P force fields for the MM part (protein, substrate and water, respectively) with electrostatic embedding

Naltrexone failed to produce consistent or clinically meaningful weight loss, even at large doses (300 mg/d) (60), implying that a single opioid mechanism is unlikely to explain all aspects of ingestive behavior

Together, this work provides a starting point for improving the understanding of the structural drivers of GPX4 interactions with its targets